Online ISSN:
3042-1772
Volume 1 , Issue 1, (2024)
Published:
29.08.2024.
Open Access
Powered by
Volume 2 Issue 1 2025
[ Forthcoming Issue ]: This issue is in progress but contains articles that are fully citable.
Authors in this issue:
Ena Šimunić, Hansjorg Habisch, Iva I Podgorski, Kate Šešelja, Marija Pinterić, Marijana Popović Hadžija, Robert Belužić, Sandra Sobocanec, Tihomir Balog, Tobias Madl,
Edited by:
Bato Korać
Author guidelines
Editorial Policy
1
Issues63
ArticlesBECOME A REVIEWER
We invite you to become an RedoXplore reviewer.
Submit your manuscript
RedoXplore runs special issues to create collections of papers on specific topics.
Archive
See all
Volume 1, Issue 1, 2024
04.11.2025.
Original scientific paper
Mitochondrial Sirt3 in Kidney Aging: Sex-Specific Links to Metabolic Homeostasis and Oxidative Stress
Purpose: Aging is a complex biological process that begins at the cellular level, disrupting energy homeostasis. This study investigated the role of Sirt3, major mitochondrial deacetylase involved in metabolic pathways, in sex-dependent changes in energy homeostasis during aging in kidney of Sirt3 WT and KO mice.
Methods: Enzymatic activity, lipid peroxidation, protein carbonylation with Western blot and metabolomic analyses were performed to assess physiological and metabolic parameters
Results: Higher Sirt3 expression in male WT mice leads to increased vulnerability to its deficiency, as reflected in the shorter lifespan of male KO mice. This is further supported by distinct metabolomic clustering in male KO mice, highlighting significant metabolic disruptions. Male-specific declines in metabolites such as creatine, phosphorylcholine, trimethylamine-N-oxide, and L-carnitine, along with reduced trifunctional multienzyme complex subunit β (HADHB) expression, point to impaired fatty acid metabolism and mitochondrial dysfunction.
Conclusions: The findings emphasize the sex-specific function of Sirt3 in regulating mitochondrial activity, energy metabolism, and oxidative stress in the murine kidney, with male mice exhibiting a greater reliance on Sirt3 for metabolic stability.
Ena Šimunić, Kate Šešelja, Iva I Podgorski, Marija Pinterić, Robert Belužić, Marijana Popović Hadžija, Tihomir Balog, Hansjorg Habisch, Tobias Madl, Sandra Sobocanec
